منابع مشابه
Factor XIII deficiency: a review of literature
Coagulaon factor XIII gene, protein structure and funcon Coagulaon factor XIII (FXIII) is a tetrameric (FXIII- A2B2) pro-transglutaminase enzyme with an essenal role in the final stage of coagulaon cascade by cross linking the fibrin monomers and stabilizing the fibrin clot. Congenital FXIII deficiency is a rare bleeding disorder, with an autosomal recessive trait inheritance, and a fre...
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Intensive research on the neurobiology of pain over the past two decades has revealed many receptors, ion channels and enzymes with potential as novel targets for development of a new generation of analgesic agents. However, despite large investment in preclinical and clinical development of small molecules and biologics as potential novel pain therapeutics, very few have reached the clinic. He...
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BACKGROUND AND OBJECTIVES Pain treatment involves the usage of common and opioid analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs) and adjuvant analgesics. Traditionally, these drugs are administered systemically or into the neuraxis. However, when analgesics are applied through these pathways, they are associated with significant side effects, which can hinder its use. Topical administ...
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Patient phenotypes in pharmacological pain treatment varies between individuals, which could be partly assigned to their genotypes regarding the targets of classical analgesics (OPRM1, PTGS2) or associated signalling pathways (KCNJ6). Translational and genetic research have identified new targets, for which new analgesics are being developed. This addresses voltage-gated sodium, calcium and pot...
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A key clinical problem in low-vision assessment is finding simple measures that are predictive of real-world performance. Our purpose was to determine whether a set of clinical variables could predict how well low-vision subjects read with their magnifiers. The variables were Snellen acuity, presence/absence of central scotomas, clear/cloudy ocular media, age, magnifier type, and score on a sta...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1958
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.78.1_6